ATF6 -Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo
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چکیده
منابع مشابه
ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo.
The pathways that allow quiescent disseminated cancer cells to survive during prolonged dormancy periods are unknown. Here, we identify the transcription factor ATF6alpha as a pivotal survival factor for quiescent but not proliferative squamous carcinoma cells. ATF6alpha is essential for the adaptation of dormant cells to chemotherapy, nutritional stress, and, most importantly, the in vivo micr...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0800939105